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Published on: October 10, 2019

The association between hyperglycaemia and elevated troponin levels on mortality in acute coronary syndromes

Christopher P Gale1, Chetan Kashinath, Paul Brooksby

  • 1Academic Unit of Cardiovascular Medicine, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. medcpg@medphysics.leeds.ac.uk

Diabetes & Vascular Disease Research
|October 25, 2006
PubMed

Insights

Hyperglycaemia (high blood glucose) significantly increases one-year mortality risk in acute coronary syndrome patients. Even with guideline adherence, high glucose levels confer a long-term survival disadvantage.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Medicine

Background:

  • Diabetes mellitus is a known risk factor for cardiovascular disease.
  • Hyperglycaemia is frequently observed in patients with acute coronary syndromes (ACS).
  • The prognostic impact of hyperglycaemia on mortality in ACS patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between hyperglycaemia, troponin I levels, and one-year mortality in patients hospitalized with ACS.
  • To determine if hyperglycaemia independently predicts mortality in this patient cohort.

Main Methods:

  • Prospective study of 498 patients admitted with acute coronary syndrome.
  • Measurement of random glucose and troponin I on admission.
  • Follow-up for one-year mortality.

Main Results:

  • Patients with hyperglycaemia (random glucose > 11.1 mmol/L) had a significantly higher proportion of deaths (27%) compared to those without (12%, p=0.002).
  • Elevated troponin I concentrations on admission were associated with increased mortality (p<0.001).
  • Myocardial infarction presence increased the risk of death (relative risk = 1.85).

Conclusions:

  • Hyperglycaemia is a significant independent predictor of long-term mortality in patients with acute coronary syndrome.
  • Even with optimal management, hyperglycaemia poses a substantial mortality risk.
  • Close monitoring and management of glucose levels in ACS patients are crucial for improving outcomes.

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