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Updated: Jul 19, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Assessment on effects of tongjiang granule on experimental reflux esophagitis in rats]
Xu-dong Tang1, Hong-mei Wu, Zhi-bin Wang
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing. txdly@sina.com.cn
Objective:
To study the effects of tongjiang granule (TJG) on reflux esophagitis (RE) in rats.
Methods:
Two rat models of RE were established respectively by cardioplasty + pyloric ligation + Roux-en-Y gastro-jejunum anastomosis and by placed a fixed steel ring into the gastric cardia, and the model rats were treated with various dosages of TJG or cisapride by gastric perfusion.
Results:
Rat models were established successfully by both methods. The score of pathological changes of esophagus mucosa in the model rats, made by either method, after high-dosage TJG treatment was lower than that in the model rats (P < 0.05), but equal to that in the cisapride treated model rats. High and moderate dosages of TJG were shown by transmission electron microscope to have effects of alleviating heckle cells and inflammatory reaction. They could reduce the level of gastric acid, more significant in high and moderate dosage groups (P < 0.05), while cisapride couldn't.
Conclusion:
TJG is effective in treating experimental RE in rats to a certain extent.
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