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Why does pancreatic overstimulation cause pancreatitis?

Ashok K Saluja1, Markus M Lerch, Phoebe A Phillips

  • 1Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. asaluja@umn.edu

Annual Review of Physiology
|October 25, 2006
PubMed

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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