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One-anastomosis Gastric Bypass (OAGB) in Rats
Published on: November 10, 2018
Gastric bypass for morbidly obese patients with established cardiac disease
Grady D Alsabrook1, Hope R Goodman, J Wesley Alexander
1The Center for Surgical Weight Loss, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Insights
Roux-en-Y gastric bypass (RYGBP) is safe and effective for morbidly obese patients with cardiac disease, improving comorbidities. Longer-term data are needed, but initial results show acceptable risks and benefits for this population.
Area of Science:
- Cardiology
- Bariatric Surgery
- Obesity Medicine
Background:
- Bariatric surgery is often avoided in cardiac patients due to perceived risks.
- Roux-en-Y gastric bypass (RYGBP) is a common bariatric procedure.
- Obesity is a significant risk factor for cardiac disease.
Purpose of the Study:
- To evaluate the risks and benefits of RYGBP in morbidly obese patients with established cardiac disease.
- To compare outcomes in patients with cardiac disease versus a control group without cardiac disease.
Main Methods:
- Retrospective analysis of 77 consecutive patients with cardiac disease undergoing RYGBP.
- Comparison of preoperative and postoperative cardiac risk factors, complications, and BMI changes.
- Control group without cardiac disease for comparison.
Main Results:
- Cardiac disease presentations included coronary artery disease (CAD) and congestive heart failure (CHF).
- Patients with cardiac disease had high rates of diabetes, hypertension, and hyperlipidemia.
- All comorbidities improved post-RYGBP; no cardiac deaths occurred, though other complications were noted.
Conclusions:
- RYGBP appears to have acceptable risks for patients with existing cardiac disease.
- The procedure effectively reduces comorbidities such as diabetes, hypertension, and hyperlipidemia.
- Longer-term data are required to fully assess the benefits and risks of RYGBP in this population.
Background:
Bariatric surgery has often been avoided in patients with known cardiac disease because of the risks inherent in this patient population. This study was done to evaluate both the risks and benefits of Roux-en-Y gastric bypass (RYGBP) in morbidly obese patients with established cardiac disease.
Methods:
Data were analyzed to compare preoperative with postoperative co-morbid cardiac risk factors, peri-operative and postoperative complications, and change in body mass index (BMI) in 77 consecutive patients who had a preoperative diagnosis of cardiac disease and underwent RYGBP between March 1998 and January 31, 2006. Findings were compared to a concomitant control group without cardiac disease.
Results:
The preoperative presence of cardiac disease was manifested primarily as coronary artery disease (CAD) (45 patients) or as congestive heart failure (CHF) (32 patients). Of the patients with CAD, 60% had diabetes, 91% had hypertension and 39% had hyperlipidemia. 58% had one or more prior invasive cardiac procedures. In the CHF group, 50% had diabetes, 71% had hypertension and 44% had hyperlipidemia. The average length of stay was 3.7 days for CAD patients and 3.3 days for CHF compared to 3.0 days for controls. All co-morbid conditions were improved, and no patient died from cardiac disease. However, one patient died as a complication of GI bleeding, one patient subsequently underwent revascularization and another underwent stenting. Other complications up to 5 years postoperatively were frequent but seldom life-threatening.
Conclusion:
RYGBP surgery in patients with existing cardiac disease appears to have acceptable risk and is effective in reducing the co-morbid conditions of diabetes, hypertension, hyperlipidemia, sleep apnea and arthritis, but longer term data are needed.
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