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Updated: Jul 19, 2026

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
Published on: August 11, 2011
[Development of research on tumor dormancy]
Guo-Wei Che1, Lun-Xu Liu, Qing-Hua Zhou
1Department of Cardiovascular Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China. cheguowei@yahoo.com.cn
Abstract:
Tumor dormancy is not only a biologic character in malignant tumor cells but also the key cause of failure to the treatment, metastasis, and recurrence of tumors. In this article, the evidence of tumor dormancy in patients, the evolution of the definition of tumor dormancy, the establishment of the animal mode of tumor dormancy, and the molecular mechanism of tumor dormancy were reviewed. Recent progress on novel antitumor drugs through inducing tumor dormancy was summarized.
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