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Lethal somatostatin analog-induced acute necrotizing pancreatitis in a patient with hormone-refractory prostate

Michele Battaglia1, Pasquale Ditonno, Silvano Palazzo

  • 1Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. battaglia@urologia.uniba.it

Scandinavian Journal of Urology and Nephrology
|October 25, 2006
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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...