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Malabsorption in psoriatic patients: cause or consequence?

Veronica Ojetti1, Clara De Simone, Jose Aguilar Sanchez

  • 1Department of Internal Medicine, Catholic University, Rome, Italy. veronica.ojetti@tin.it

Scandinavian Journal of Gastroenterology
|October 25, 2006
PubMed
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Malabsorption is significantly more common in psoriasis patients, affecting 60%. Conditions like celiac disease and bacterial overgrowth may contribute to gut issues in psoriasis.

Area of Science:

  • Gastroenterology
  • Dermatology
  • Internal Medicine

Background:

  • Psoriasis pathogenesis remains unclear, but gut-skin disease associations are recognized.
  • Psoriatic patients exhibit a higher prevalence of celiac disease.
  • Small-bowel abnormalities can lead to malabsorption, presenting clinically or subclinically.

Purpose of the Study:

  • To determine the prevalence of malabsorption in patients with psoriasis.
  • To investigate potential gastrointestinal causes of malabsorption in psoriatic individuals.

Main Methods:

  • A D-xylose absorption test was administered to 55 psoriatic patients and 65 healthy controls.
  • Positive cases underwent further testing: antibody panels (antigliadin, anti-endomysium, anti-transglutaminase), H2 lactulose breath test, fecal parasitology, and colonoscopy with ileoscopy.

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Main Results:

  • 60% of psoriatic patients (33/55) showed altered D-xylose absorption, compared to 3% of controls (2/65).
  • Among psoriatic patients with malabsorption, diagnoses included celiac disease (6%), bacterial overgrowth (21%), parasitic infections (3%), and eosinophilic gastroenteritis (1 patient).

Conclusions:

  • Malabsorption is significantly more prevalent in psoriatic patients than in the general population.
  • Potential causes of malabsorption in psoriasis include celiac disease, bacterial overgrowth, parasitic infections, and eosinophilic gastroenteritis.
  • Further research is essential to elucidate the pathogenesis and gut-skin disease associations in psoriasis.