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Updated: Jul 19, 2026

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
Symptoms and disability until 3 months after mild TBI
A Lundin1, C de Boussard, G Edman
1Department of Psychiatry, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. anders.lundin@ds.se
Most mild traumatic brain injury (MTBI) patients experience symptom decline within 3 months. However, early high symptom load indicates a risk for persistent post-concussion symptoms and related disability.
Area of Science:
- Neurology
- Traumatology
- Rehabilitation Medicine
Background:
- Mild traumatic brain injury (MTBI) is a common neurological condition.
- Understanding the post-injury symptom trajectory and its impact on daily functioning is crucial for patient management.
Purpose of the Study:
- To investigate the frequency, characteristics, and progression of symptoms up to 3 months after MTBI.
- To determine the relationship between symptom experience and functional disability post-MTBI.
Main Methods:
- A prospective cohort study involving 122 patients diagnosed with MTBI.
- Symptom assessment utilized the Rivermead Post-concussional Questionnaire at 1, 7, 14 days, and 3 months.
- Disability was evaluated using the Rivermead Head Injury Follow-up Questionnaire.
Main Results:
- Symptom reporting decreased from 86% at day 1 to 49% at 3 months post-injury.
- At 3 months, 25% of patients reported changes in daily activities.
- Commonly reported symptoms included memory difficulties, sleep disturbances, and fatigue.
- Significant correlations were found between symptom and disability scores (tau = 0.60) and between early and late symptom loads (tau = 0.38).
Conclusions:
- Symptoms following MTBI generally show a gradual decline over 3 months.
- Persistent symptoms at 3 months correlate significantly with functional disability.
- Patients presenting with a high symptom load early after injury are at increased risk for developing long-term complaints.
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