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Updated: Jul 19, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Clinical phenotype of an Italian family with a new mutation in the PRPF8 gene
F Testa1, C Ziviello, M Rinaldi
1Department of Ophthalmology, Second University of Napoli, Napoli, Italy.
Purpose:
To report the clinical and functional characteristics of an autosomal dominant retinitis pigmentosa (ADRP) family with a novel point mutation (P2301S) in the PRPF8 gene.
Methods:
PRPF8 gene analysis and complete ophthalmologic examination in an ADRP family.
Results:
Clinical examination revealed the typical RP phenotype in all family members. Electroretinography showed preserved ERG photopic responses. Genetic analysis showed that the P2301S missense mutation segregated with the disease in all subjects.
Conclusions:
Unlike previously reported families, the PRPF8 gene mutation in our family is associated with a mild phenotype in which cone function is partially preserved.
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