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Updated: Jul 19, 2026

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay (DRaCALA)
Published on: March 19, 2021
[Proteins with GGDEF and EAL domains: their role in bacterial metabolism]
Micaela Marcela Méndez-Ortiz1, Jorge Membrillo-Hernández
1Laboratorio de Microbiología y Genética Molecular, Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
Abstract:
The availability of multiple bacterial genome sequences has led to the discovery of several conserved domains of proteins. Recently, GGDEF and EAL domains have been described as domains responsible for the synthesis and degradation of c-di-GMP, a second messenger in bacteria. c-di-GMP has been involved in cellulose production and identified as a global regulator of several processes such as biofilm formation, motility and virulence, presumibly through a modification of the cell surface properties.
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