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[Chemical constituents from Viscum nudum and their accelerating PC12 cell differentiation]
Hai-Yan Zhu1, Zheng-Wen Yu, Xiao-Sheng Yang
1The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
Objective:
To investigate chemical constituents of the stem of Viscum nudum and their bioacyivity.
Method:
The major chemical constituents were isolated from the AcOEt-solved part of ethanol-extract of the plant by column chromatography and the active screening test in vitro were taken out for looking for compounds to acccelerate PC12 cell differentiation.
Result:
5 compounds were identified as eriodictyol (1), 5, 7-dihydroxy-3', 4'-dimethoxy flavanone (2), oleanolic (3), 5, 7-dihydroxychromone (4) and homeriodictyol (5) by spectral evidences, in which homeriodictyol (5) had acceleration differentiation to PC12 cell.
Conclusion:
All compounds were obtained from this plant for the first time, and bioactive constituent was observed in the AcOEt-solved part.
