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Published on: March 11, 2017
Stability of vancomycin in icodextrin peritoneal dialysis solution
Adwoa O Nornoo1, Rowland J Elwell
1Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208-3492, USA. nornooa@acp.edu
The Annals of Pharmacotherapy
|October 26, 2006
Summary
Vancomycin in icodextrin peritoneal dialysis (PD) solutions remains stable for up to seven days when refrigerated or at room temperature. Solutions stored at body temperature are stable for 24 hours, allowing for prewarming before administration.
Area of Science:
- Pharmaceutical Science
- Nephrology
- Clinical Pharmacy
Background:
- Icodextrin is a glucose polymer utilized as an osmotic agent in peritoneal dialysis (PD) solutions.
- Limited data exist on the long-term stability of vancomycin within icodextrin-based PD solutions.
Purpose of the Study:
- To assess the chemical stability of vancomycin in icodextrin PD solutions.
- To evaluate stability in polyvinyl chloride containers over a 7-day period at various temperatures (4°C, 24°C, and 37°C).
Main Methods:
- Vancomycin HCl (2000 mg) was added to 2.0 L bags of 7.5% icodextrin PD solution.
- Nine samples were stored at 5°C, 24°C, and 37°C.
- Vancomycin concentration was measured using high-performance liquid chromatography over 7 days, with visual inspections for degradation.
Main Results:
- At 5°C, 99.7% of vancomycin remained after 7 days.
- At 24°C, 97.5% of vancomycin remained after 7 days.
- At 37°C, 94.3% of vancomycin remained after 24 hours.
Conclusions:
- Premixed vancomycin-icodextrin PD solutions are stable for up to 7 days when refrigerated or stored at room temperature.
- Refrigeration is recommended for optimal stability.
- Stability at 37°C for 24 hours supports prewarming solutions before administration.
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