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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

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Plain computed tomography for assessment of early coronary microcirculatory damage after revascularization therapy in

Masaya Kato1, Keigo Dote, Shota Sasaki

  • 1Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima 731-0221, Japan. ms-katou@asa-hosp.city.hiroshima.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 26, 2006
PubMed

Insights

Myocardial contrast enhancement on CT scans after reperfusion therapy indicates coronary microcirculatory damage in acute myocardial infarction (MI). A relative CT number effectively evaluates impaired microcirculation.

Area of Science:

  • Cardiology
  • Radiology
  • Cardiovascular Imaging

Background:

  • Coronary microcirculatory damage significantly impacts prognosis after acute myocardial infarction (MI) revascularization.
  • Myocardial contrast enhancement on computed tomography (CT) post-revascularization may indicate hemorrhagic infarction.
  • This study investigates the link between myocardial contrast enhancement and coronary microcirculatory damage.

Purpose of the Study:

  • To determine if myocardial contrast enhancement detected by CT after coronary reperfusion therapy correlates with coronary microcirculatory damage in acute MI patients.
  • To assess the utility of a relative CT number in evaluating the microcirculatory state.

Main Methods:

  • Thirteen patients with acute anterior MI receiving revascularization within 6 hours of symptom onset were studied.
  • Coronary flow velocity was measured using a Doppler guidewire.
  • Chest CT scans were performed immediately post-revascularization, calculating a relative CT number (highest-enhanced myocardium to left ventricle lumen ratio).

Main Results:

  • The relative CT number showed a significant negative correlation with coronary diastolic deceleration time (r=-0.78, p<0.002).
  • A significant positive correlation was observed between the relative CT number and coronary diastolic deceleration rate (r=0.74, p<0.04).
  • The relative CT number also correlated with peak plasma myocardial enzyme release.

Conclusions:

  • Plain CT-detected myocardial contrast enhancement after coronary reperfusion signifies coronary microcirculatory damage in acute MI.
  • The relative CT number serves as a valuable metric for assessing impaired coronary microcirculation.
Abstract

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