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Related Experiment Video

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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

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Published on: May 23, 2025

The relationship between depression and serum ferritin level.

M Vahdat Shariatpanaahi¹, Z Vahdat Shariatpanaahi, M Moshtaaghi

¹Department of Psychiatry, Free Islamic University of Medical Sciences, Tehran, Iran.

European Journal of Clinical Nutrition

|October 26, 2006

Summary

This study found that depressed female students had significantly lower serum ferritin levels. Low ferritin levels were associated with increased odds of depression, suggesting a link before anemia develops.

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Area of Science:

Biochemistry
Psychiatry
Hematology

Background:

Depression is a prevalent mental health disorder.
Serum ferritin is a key indicator of iron storage in the body.
Iron deficiency, indicated by low ferritin, may impact mental health.

Purpose of the Study:

To investigate the association between depression and serum ferritin levels in female medical students.
To determine if low serum ferritin is a risk factor for depression.
To explore the relationship before the onset of anemia.

Main Methods:

A case-control study was conducted with 192 female medical students.
Depression was diagnosed using the Beck depression inventory.
Serum ferritin levels were measured alongside hemoglobin, ESR, CRP, folic acid, and vitamin B12.

Main Results:

The prevalence of depression was 34.7% in the study population.
Students with depression exhibited significantly lower mean serum ferritin levels compared to healthy controls (P<0.001).
A low ferritin level increased the odds of depression by 1.92 (P<0.05).

Conclusions:

A potential association exists between depression and reduced serum ferritin levels.
Decreased ferritin may precede the development of anemia in individuals with depression.
These findings highlight the importance of monitoring iron status in mental health assessments.