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Lack of association between iron status at birth and growth of preterm infants
Rosely Sichieri1, Vania Matos Fonseca, Daniel Hoffman
1Instituto de Medicina Social, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brasil. sichieri@ims.uerj.br
Insights
Maternal anemia did not affect preterm infants
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Hematology
Background:
- Preterm infants are at risk for growth complications.
- Iron status at birth is a potential factor influencing infant development.
Purpose of the Study:
- To investigate the relationship between iron status at birth and the growth of preterm infants.
- To determine if maternal iron status or anemia at birth impacts infant growth.
Main Methods:
- Followed 95 preterm infants (26-36 weeks gestational age) for six months.
- Measured iron status (hemoglobin, hematocrit, plasma iron) in mothers and infants at birth.
- Utilized multivariate linear regression to analyze factors associated with linear growth.
Main Results:
- Infant growth rate varied with gestational age, slowing after 40 weeks.
- Birth weight and gestational age were significant predictors of growth.
- No association was found between maternal or infant iron status at birth and infant growth.
- Maternal anemia prevalence was high (43.9%), but not correlated with infant anemia.
Conclusions:
- Maternal anemia at birth does not appear to increase anemia risk in preterm infants.
- Infant iron status at birth is not associated with short-term growth in preterm infants.
- Further research may explore other factors influencing preterm infant growth.
Objective:
To assess the association between iron status at birth and growth of preterm infants.
Methods:
Ninety-five premature babies (26 to 36 weeks of gestational age) born from July 2000 to May 2001 in a public hospital in Rio de Janeiro, Southeastern Brazil, were followed up for six months, corrected by gestational age. Iron measurements at birth were available for 82 mothers and 78 children: hemoglobin, hematocrit, mean corpuscular volume and plasma iron. All children received free doses of iron supplement (2 mg/kg/day) during the follow-up period and up to two years of age. Multivariate linear regression analyses with repeated measurements were performed to assess factors associated to linear growth.
Results:
Growth was more pronounced up to 40 weeks of gestational age, increasing about 1.0 cm/week and then slowing down to 0.75 cm/week. The multivariate analysis showed growth was positively associated with birth weight (0.4 cm/100 g; p<0.001) and negatively associated with gestational age at birth (-0.5 cm/week; p<0.001). There was no association between cord iron and mother iron measurements and growth (p>0.60 for all measures). Only two children had anemia at birth, whereas 43.9% of mothers were anemic (hemoglobin <11 g/dl). Also, there was no correlation between anemia indicators of mothers and children at birth (r<0.15; p>0.20).
Conclusions:
Maternal anemia was not associated with anemia in preterm infants and iron status of mothers and children at birth was not associated with short-term growth of preterm infants.
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