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Updated: Jul 19, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Implementation of standard operating procedures for the initial empirical antimicrobial therapy for adults--a new
Irit Nachtigall1, Maria Deja, Elke Halle
1Klinik für Anästhesiologie und operative Intensivmedizin, Charite--Universitätsmedizin Berlin, Campus Virchow-Klinikum und Campus Charité Mitte.
Abstract:
Nowadays 40-50 % of the patients receive inappropriate antibiotic treatment. Evidence based recommendations are not considered and there is an increasing burden of resistant pathogens. Therefore, standard operating procedures (SOPs) should be implemented considering guidelines and resistant species in the specific ICU. The authors developed algorithms and generated a user friendly computer program available for all ICU physicians all the time.
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