Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hepatocyte growth factor and kidney].

C Esposito1, G Fasoli, T Rampino

  • 1Unità Operativa di Nefrologia, Dialisi e Trapianto, IRCCS Policlinico San Matteo, Università di Pavia, Pavia. espositociro56@hotmail.com

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|October 26, 2006
PubMed
Summary

Hepatocyte Growth Factor (HGF) promotes kidney cell survival and repair, offering a promising therapeutic strategy for chronic kidney diseases by reducing fibrosis and improving tissue remodelling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cone Beam CT-guided Online Adaptive Radiotherapy for Prostate Stereotactic Body Radiation Therapy.

Practical radiation oncology·2026
Same author

From models to medicine: advanced preclinical systems and AI enabling RNA therapeutics in triple-negative breast cancer.

European review for medical and pharmacological sciences·2026
Same author

The application of EPSiT in pilonidal sinus disease: an international Delphi consensus study endorsed by the Association of Laparoscopic Surgeons of Great Britain and Ireland (ALSGBI).

Techniques in coloproctology·2025
Same author

Buccal micronucleus cytome assay to evaluate cyto-genotoxic effects of occupational exposure to antineoplastic drugs: application on a large sample size of workers furnished by an Italian network of oncological hospitals.

Archives of toxicology·2025
Same author

Bioarchaeology aids the cultural understanding of six characters in search of their agency (Tarquinia, ninth-seventh century BC, central Italy).

Scientific reports·2024
Same author

Metal(loid)s and Rare Earth Elements in Posidonia oceanica (L.) Delile (1813) banquettes.

Marine pollution bulletin·2024

Area of Science:

  • Nephrology
  • Molecular Biology
  • Cell Biology

Context:

  • Hepatocyte Growth Factor (HGF) is a key signaling molecule involved in embryonic development and tissue repair.
  • The HGF receptor, c-met, a receptor tyrosine kinase, is widely expressed in renal cells.
  • HGF plays a crucial role in kidney development and recovery from acute kidney injury.

Purpose:

  • To explore the multifaceted roles of HGF in kidney physiology and pathology.
  • To investigate the therapeutic potential of HGF in chronic renal diseases, particularly in mitigating fibrosis and sclerosis.
  • To elucidate the molecular mechanisms underlying HGF's protective effects in the kidney.

Summary:

  • HGF exhibits mitogenic, motogenic, and morphogenic effects mediated through its receptor c-met.

Related Experiment Videos

  • HGF promotes cell survival by inhibiting apoptosis (upregulating Bcl-2, downregulating Bax) and enhances recovery from acute renal failure.
  • HGF exerts antifibrotic effects by antagonizing TGF-beta signaling, modulating extracellular matrix turnover (increasing MMPs, decreasing TIMPs), and inhibiting the TGF-beta/Smad pathway.

    • Impact:

    • HGF demonstrates significant potential in reducing interstitial fibrosis and glomerular sclerosis in various kidney disease models.
    • Modulation of extracellular matrix turnover and TGF-beta signaling by HGF suggests a beneficial role in renal tissue remodelling.
    • Supplementation or induction of HGF presents a viable therapeutic strategy for managing and treating chronic kidney diseases.