Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carboplatin hypersensitivity reactions.

Debra Winkeljohn1, Martha Polovich

  • 1Hematology Oncology Associates, Albuquerque, NM, USA. dwinkeljohn@comcast.net

Clinical Journal of Oncology Nursing
|October 27, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a unified approach to hazardous medicinal product management using closed system drug transfer devices.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same author

Predictor Factors Associated With Hazardous Drug Safe Handling Precautions Across a UK Oncology Nurse Sample and Implications for Novel Treatments.

Seminars in oncology nursing·2025
Same author

Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology: ASCO-ONS Standards.

Oncology nursing forum·2024
Same author

Cancer Drug Safety Training: Comparing Distance and In-Person Simulations for Interprofessional Education.

Journal of interactive learning research·2024
Same author

Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology: ASCO-ONS Standards.

JCO oncology practice·2024
Same author

Evaluation of an Interprofessional Training Program to Improve Cancer Drug Therapy Safety.

JCO oncology practice·2021

Hypersensitivity reactions (HSRs) to carboplatin chemotherapy can be severe and life-threatening. Oncology nurses manage HSRs with interventions, while skin testing and desensitization may help predict and prevent reactions.

Area of Science:

  • Oncology
  • Clinical Pharmacy

Background:

  • Carboplatin is a widely used chemotherapy agent for various cancers, including lung, breast, and ovarian.
  • Hypersensitivity reactions (HSRs) are a significant concern, often occurring after multiple doses.

Observation:

  • Oncology nurses frequently observe HSRs, which can range from mild to life-threatening.
  • Common symptoms include flushing, rash, nausea, breathing difficulties, hypotension, and tachycardia.

Findings:

  • Interventions involve supportive care (oxygen, IV hydration) and medications to mitigate HSRs.
  • Skin testing after seven or more carboplatin doses can predict HSRs.
  • Desensitization protocols may be effective for patients with positive skin tests.

Implications:

Related Experiment Videos

  • Careful consideration of the risk-to-benefit ratio is crucial for patients and physicians when using carboplatin.
  • Early identification and management of HSRs are vital for patient safety in carboplatin therapy.