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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Novel 1,4-homofragmentation via an alpha-lactone

Jollie D Godfrey1, Rita T Fox, Frederic G Buono

  • 1Department of Process Research and Development, Pharmaceutical Research Institute, Bristol-Myers Squibb, Post Office Box 4000, Princeton, New Jersey 08543-4000, USA. jollie.godfrey@bms.com

The Journal of Organic Chemistry
|October 27, 2006
PubMed
Summary

A novel reaction pathway complicates the synthesis of alpha-keto acids from dichloroesters. Researchers identified an alpha-lactone intermediate, enabling a new process for exclusive alpha-keto acid production.

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