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Updated: Jul 19, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Baroreflex activation for the treatment of hypertension: principles and practice
Domenic A Sica1, Thomas E Lohmeier
1Section of Clinical Pharmacology and Hypertension, Virginia Commonwealth University Health System, Division of Nephrology, Box 980160, MCV Station, Richmond, VA 23298-0160, USA. dsica@hsc.vcu.edu
Abstract:
This article reviews the history and current status of an innovative nonpharmacological approach for the treatment of resistant hypertension - chronic electrical activation of the afferent limb of the carotid baroreflex. Recent studies in both normotensive and hypertensive canine models have unambiguously demonstrated sustained and clinically relevant reductions in arterial pressure and sympathetic activity in the course of prolonged baroreflex activation. Clinical trials designed to evaluate the efficacy and safety of this therapy in patients with resistant hypertension are now underway in both Europe and the USA.
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