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Updated: Jul 19, 2026
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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
[Study of the proteins associated with Sa antigen]
Hua Chen1, Zhi-jian Yao, Fu-lin Tang
1Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi
|October 27, 2006
Summary
Citrullinated vimentin is closely correlated with Sa antigen, a target for rheumatoid arthritis antibodies. This finding advances understanding of autoimmune targets in rheumatic diseases.
Area of Science:
- Rheumatology
- Immunology
- Proteomics
Context:
- Rheumatoid arthritis (RA) is associated with specific autoantibodies.
- The Sa antigen is a known target of anti-Sa antibodies in RA.
- Identifying the precise nature of Sa antigen is crucial for understanding RA pathogenesis.
Purpose:
- To identify the protein components of Sa antigen.
- To determine the relationship between Sa antigen and other known autoantigens.
- To investigate the diagnostic potential of identified proteins in rheumatic diseases.
Summary:
- Sa antigen was extracted and analyzed using LC-ESI-MS/MS, identifying vimentin as the target protein.
- Anti-vimentin antibodies showed lower sensitivity and specificity for RA compared to anti-Sa antibodies.
- Anti-citrullinated vimentin antibodies demonstrated a high correlation with anti-Sa antibodies, suggesting citrullinated vimentin is closely related to Sa antigen.
Impact:
- Identifies citrullinated vimentin as a key component associated with Sa antigen.
- Provides insights into the molecular targets of autoantibodies in rheumatoid arthritis.
- May contribute to the development of improved diagnostic markers for RA.
