Related Experiment Video
Updated: Jul 19, 2026
11:28
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
[Immunopathological changes of micro-vessels in dermatomyositis].
Guang-li Shen1, He Lü, Hong-yan Bi
1Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Zhonghua Yi Xue Za Zhi
|October 27, 2006
Summary
Dermatomyositis involves micro-vessel damage beyond capillaries. Reduced expression of thrombomodulin (TM) and endothelial cell nitric oxide synthase (eNOS) impairs vascular functions, indicating dermatomyositis is an inflammatory vascular endothelial disease.
Area of Science:
- Immunopathology
- Vascular Biology
- Dermatology
Context:
- Dermatomyositis is an idiopathic inflammatory myopathy.
- Micro-vascular changes are implicated in dermatomyositis pathogenesis.
- Understanding these changes is crucial for diagnosis and treatment.
Purpose:
- To investigate the immunopathological alterations in micro-vessels within dermatomyositis.
- To characterize the expression of key endothelial markers in affected micro-vessels.
Summary:
- Muscle biopsies from 12 dermatomyositis patients revealed perifascicular atrophy and inflammation.
- Immunohistochemistry showed reduced expression of von Willebrand factor (vWF), thrombomodulin (TM), and endothelial cell nitric oxide synthase (eNOS) in micro-vessels, particularly in the perifascicular region.
- These findings indicate impaired anticoagulation and vasodilation functions.
Impact:
- Dermatomyositis involves micro-vessel damage, not just capillaries.
- Reduced TM and eNOS expression suggests endothelial dysfunction.
- This study supports classifying dermatomyositis as an inflammatory vascular endothelial disease.
Related Concept Videos
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...