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HTLV-I-associated myelopathy in a Californian: diagnosis by reactivity to a viral recombinant antigen
L S Honig1, J J Lipka, K Y Young
1Department of Neurology and Neurological Sciences, Stanford University Medical Center, CA.
Neurology
|March 1, 1991
Abstract:
A male patient developed leg numbness and weakness, and bowel, bladder, and erectile dysfunction. Examination revealed an isolated thoracic myelopathy, with lower-extremity spasticity, decreased vibration and position sense, hyperreflexia, and Babinski's signs. Serum and CSF showed antibody reactivity to human T-cell lymphotropic virus type I or II (HTLV-I/II), suggesting HTLV-I-associated myelopathy. Antibody reactivity to a unique HTLV-I recombinant protein provided definitive diagnosis of HTLV-I infection.