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cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands
G Spoto1, M della Malva, C Rubini
1Department of Applied Sciences of Oral and Dental Diseases, G D'Annunzio University, Chieti, Italy. cercando_luca@hotmail.com
Abstract:
The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups. The value of the enzymatic activity in the groups analysed was 50% lower than control samples. The differences between the control group (82 +/- 7.9 nmols/mg of protein) and the 3 pathologic groups (Benign A: 44 +/- 6.2; Malignant A: 40 +/- 16; Benign B: 40 +/- 14.2; Malign A: 9.1; Benign C: 22 nmols/mg of protein) are statistically significant.