Related Experiment Video
Updated: Jul 19, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Interacting partners of M-PMV nucleocapsid-dUTPase
V Németh-Pongrácz1, J Snasel, M Rumlova
1Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary. pongracz@enzim.hu
Abstract:
The nucleocapsid-dUTPase protein of Mason-Pfizer monkey virus is a truly bifunctional fusion enzyme. The exact role of this fusion protein in the viral life cycle is unclear. To explore its function, we started to identify interacting protein partners of the enzyme in vitro. Three viral proteins, integrase, capsid and nucleocapsid, were found to be capable of physical interaction with NC-dUTPase. Integrase protein is an important component within the preintegration complex; therefore the present results also suggest that NC-dUTPase might be associated with this complex.
Related Concept Videos
Inhibitors of Virion Maturation and Assembly
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Inhibitors Of Virion Release
Antiviral Nucleoside Inhibitors
Coat Assembly and GTPases
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
DNA Bacteriophages

