Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive enhancement with central thalamic electrical stimulation.

Prasad Shirvalkar1, Malika Seth, Nicholas D Schiff

  • 1Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 27, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated EEG Classification to Track Levels of Consciousness.

medRxiv : the preprint server for health sciences·2026
Same author

Predicting pain location from resting-state brain fMRI.

bioRxiv : the preprint server for biology·2026
Same author

Improved autobiographical memory with central thalamic deep brain stimulation in traumatic brain injury.

Brain communications·2026
Same author

Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.

Journal of neural engineering·2026
Same author

Neurophysiological correlates of delayed recovery of consciousness in a critically ill patient with COVID-19 with repeated cardiac arrest.

British journal of anaesthesia·2026
Same author

Determinants of Delayed Recovery of Consciousness After Analgosedation Discontinuation in the ICU: Insights From Patients With COVID-19 Hypoxemic Respiratory Failure.

Critical care medicine·2026

Central thalamic electrical stimulation enhances cognitive function by activating brain regions involved in alertness and memory. This method boosts gene expression in the cortex and hippocampus, improving cognitive performance in rodents.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurobiology

Background:

  • Central thalamus plays a crucial role in maintaining alertness and attention.
  • Electrical stimulation of the central thalamus is a potential therapeutic approach for cognitive impairments.

Purpose of the Study:

  • To investigate the effects of central thalamic electrical stimulation on brain activity and cognitive function.
  • To determine if central thalamic stimulation can improve cognitive performance and modulate gene expression.

Main Methods:

  • Continuous high-frequency (100 Hz) electrical stimulation of the central thalamus in rodents.
  • Measurement of immediate early gene expression (c-fos and zif268) in cortical and hippocampal tissues.
  • Assessment of goal-directed behavior, object recognition memory, and exploratory activity.

Related Experiment Videos

Main Results:

  • Widespread cortical activation of c-fos and selective regulation of zif268 in cortical laminae.
  • Significant elevation of immediate early genes in the dentate gyrus of the hippocampus.
  • Facilitation of untrained goal-directed seeking behavior and object recognition memory.
  • Increased exploratory motor behaviors and grooming, indicating enhanced arousal.

Conclusions:

  • Central thalamic electrical stimulation activates neocortical and hippocampal neurons.
  • This stimulation selectively regulates gene expression in key brain regions.
  • Central thalamic stimulation shows potential for enhancing cognitive performance and arousal.