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Published on: November 16, 2016
In vitro antianaerobic activity of DX-619, a new des-fluoro(6) quinolone
Kaori Tanaka1, Hiroshige Mikamo, Ken'ichi Nakao
1Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. kktb@gifu-u.ac.jp
Abstract:
The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC(50)s/MIC(90)s of =0.03 to 0.25/=0.03 to 1 microg/ml, respectively. DX-619 was also active against imipenem-resistant Bacteroides spp., with MIC(50)s/MIC(90)s of 0.25/1 microg/ml, respectively.
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