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Adverse cutaneous reactions due to macrolides
J M Igea1, S Quirce, B de la Hoz
1Servicio de Alergia, Hospital Ramon y Cajal, Carretera de Colmenar, Madrid, Spain.
Annals of Allergy
|March 1, 1991
Abstract:
Macrolides, which are widely prescribed and seldom produce hypersensitivity reactions, are considered to be safe drugs. We present five patients with generalized skin reactions due to erythromycin and/or spiramycin, proved by oral challenge tests. One patient showed reactions to both erythromycin and spiramycin. All skin prick and patch tests and histamine release tests with both macrolides were negative.