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Related Experiment Video

Updated: Jul 19, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic technologies as platforms for performing quantitative cellular analyses in an in vitro environment.

R Scott Martin1, Paul D Root, Dana M Spence

  • 1Department of Chemistry, Saint Louis University, St. Louis, MO 63103, USA.

The Analyst
|October 27, 2006
PubMed
Summary

This tutorial reviews quantitative cellular measurements using microfluidic technologies. It guides researchers on performing in vitro analyses, addressing challenges and advantages of microfluidic devices for cell studies.

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Area of Science:

  • Cellular Biology
  • Analytical Chemistry
  • Bioengineering

Background:

  • Cellular events often occur in environments unsuitable for direct in vivo sensing.
  • In vitro analysis requires bringing cells out of their natural environment, potentially altering their behavior.
  • Existing methods face challenges with sample integrity and loss of in vivo stimuli.

Purpose of the Study:

  • To provide guidance on performing quantitative cellular measurements under in vitro conditions.
  • To review microfluidic technologies for cellular analysis, including microbore tubing and microfabricated devices.
  • To discuss the advantages and challenges associated with these microfluidic approaches.

Main Methods:

  • Review of literature on cellular analyses using microfluidic technologies.

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Last Updated: Jul 19, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
12:21

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

Published on: August 6, 2013

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Published on: April 17, 2021

  • Focus on methods involving microbore tubing and microfabricated fluidic channels.
  • Discussion of fabrication technologies, fluid handling, channel coatings, and detection schemes.

    • Main Results:

    • Microfluidic devices offer a viable alternative for in vitro cellular measurements.
    • Microfabricated devices have increased in complexity due to technological advancements.
    • Examples of cellular analyses, along with their benefits and drawbacks, are presented.

    Conclusions:

    • Microfluidic technologies are crucial for quantitative in vitro cellular analysis.
    • Advancements in fabrication and detection enhance the capabilities of microfluidic cell studies.
    • The review offers insights into optimizing cellular analyses within microfluidic systems.