Related Experiment Video
Updated: Jul 19, 2026
10:17
The Tail Suspension Test
Published on: January 28, 2012
Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients
C Nadri1, Y Bersudsky, R H Belmaker
1Stanley Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Mental Health Center, Beersheva, Israel.
Journal of Neural Transmission (Vienna, Austria : 1996)
|October 27, 2006
Summary
Urine levels of ADAM12 protein were significantly higher in bipolar patients treated with lithium compared to healthy individuals. This finding suggests a potential biomarker for lithium response in bipolar disorder.
Area of Science:
- Biochemistry
- Neuroscience
- Clinical Medicine
Background:
- ADAM12 (A Disintegrin And Metalloprotease)12 is a glycoprotein found in membranes and secreted fluids.
- Recent findings indicate ADAM12 is present in human urine.
- Bipolar disorder is a mood disorder requiring effective treatment monitoring.
Purpose of the Study:
- To investigate urinary ADAM12 protein levels in bipolar disorder patients.
- To compare ADAM12 levels between bipolar patients and healthy controls.
- To explore potential correlations between ADAM12 levels and lithium treatment.
Main Methods:
- Urine samples were collected from 19 bipolar patients and 22 healthy controls.
- Urine samples underwent concentration.
- Western-blot analysis was employed to quantify ADAM12 protein levels.
Main Results:
- The 92 kDa form of urinary ADAM12 protein was significantly elevated in lithium-treated bipolar patients compared to controls.
- No significant difference was observed in the 68 kDa form of urinary ADAM12 between groups.
- Urinary ADAM12 protein levels show potential as a biomarker in bipolar disorder.
Conclusions:
- Elevated 92 kDa urinary ADAM12 protein levels are associated with lithium treatment in bipolar disorder.
- Further research is warranted to confirm ADAM12 as a biomarker for lithium response.
- Investigating the functional role of ADAM12 in bipolar disorder pathophysiology is crucial.
More Related Videos
Related Concept Videos
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:30Bipolar Disorder
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...