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Related Experiment Video

Updated: Jul 19, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Right aortic arch in the fetus.

V Zidere¹, E G Tsapakis, I C Huggon

¹Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology

|October 27, 2006

Summary

Fetal echocardiography can detect right aortic arch, an isolated or complex congenital heart defect, from 12 weeks gestation. Increased detection suggests prior underdiagnosis, with 22q11 deletion important in complex cases.

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Area of Science:

Cardiovascular Medicine
Prenatal Diagnosis
Medical Imaging

Background:

Right aortic arch is a rare congenital anomaly.
Accurate prenatal diagnosis is crucial for management.
Fetal echocardiography is the primary imaging modality.

Observation:

A right aortic arch was diagnosed in 75 fetuses over an 8-year period.
Detection rates increased over time, suggesting improved diagnostic accuracy.
Associated intracardiac malformations and 22q11 deletions were common.

Findings:

The diagnosis can be made as early as 12 weeks gestation.
Distinguishing from a double aortic arch can be challenging.
Karyotyping may not be necessary for isolated cases, but 22q11 microdeletion status is important for complex cases.

Implications:

Improved prenatal detection of right aortic arch is possible.
Early diagnosis facilitates appropriate management and genetic counseling.
Refined diagnostic criteria may reduce missed diagnoses.