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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Major amputation incidence decreases both in non-diabetic and in diabetic patients in Helsinki
E Eskelinen1, A Eskelinen, A Albäck
1Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. elina.eskelinen@fimnet.fi
Insights
Major lower limb amputations decreased in both diabetic and non-diabetic patients. This reduction in diabetes-related amputations and critical leg ischemia amputations highlights improved prevention strategies.
Area of Science:
- Vascular Surgery
- Diabetology
- Public Health
Background:
- Diabetes mellitus is a significant risk factor for lower extremity amputations.
- Critical leg ischemia also leads to major lower limb amputations.
- Understanding amputation trends is crucial for preventative strategies.
Purpose of the Study:
- To evaluate changes in diabetes-related lower extremity amputations.
- To compare amputation rates in diabetic versus non-diabetic patients with critical leg ischemia.
- To analyze amputation trends over a 13-year period.
Main Methods:
- Retrospective analysis of 1094 major lower limb amputations for vascular disease.
- Data collected from 1990-2002 in Helsinki.
- Comparison of amputation incidence between diabetic and non-diabetic groups across three time periods.
Main Results:
- A 23% reduction in major amputations for diabetic patients from 1990-2002.
- A 40% decrease in amputations for non-diabetic patients during the same period.
- A 33% decrease in amputation incidence per million individuals with diabetes.
Conclusions:
- Amputation rates have declined in both diabetic and non-diabetic populations.
- Increased focus on amputation prevention strategies likely contributed to the observed decrease.
- Vascular surgeons play a key role in reducing lower limb amputations.
Background And Aims:
The aim of the study was to assess the changes in diabetes-related lower extremity amputations and to compare it with the development of amputations for critical leg ischaemia in patients without diabetes.
Material And Methods:
Clinical records of 1094 patients undergoing major lower limb amputations for vascular disease in the town of Helsinki during 13 years from 1990 to 2002 were analyzed retrospectively. Data concerning patient factors, diagnosis, existence of diabetes and amputation level were recorded. The study period was divided into three parts (1990-1994, 1995-1998 and 1999-2002) and results were compared between diabetic and nondiabetic vascular amputees during these time periods.
Results:
From 1990 through 2002, 561 of patients undergoing major lower limb amputation had diabetes mellitus. The overall incidence of major amputations of diabetics reduced from the first time period to the last period by 23%. At the same time, the incidence of amputations in non-diabetic patient group decreased 40%. If the incidence rate for amputations is expressed per million individuals with diabetes, 33% decrease was observed during the study period.
Conclusions:
The decrease in major amputation rates among diabetic as well as non-diabetic patients can be attributed to the increased interest in amputation prevention, with a contribution by vascular surgeons being made in both groups.
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