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Updated: Jul 19, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Indole alkaloids from Cephalanceropsis gracilis
Pei-Lin Wu1, Yu-Lin Hsu, Chen-Wei Jao
1Department of Cosmetic Science, Chung Hwa College of Medical Technology, Tainan, 717, Taiwan, Republic of China. wupl@mail.ncku.edu.tw
Abstract:
Purification of CHCl3 and EtOAc solubles of the MeOH extract of Cephalanceropsis gracilis afforded seven new indole alkaloids, cephalinones A (1), B (2), C (3), and D (4) and cephalandoles A (5), B (6), and C (7), besides eight known compounds. The structures of the new compounds were determined by spectroscopic analysis. All 15 indole alkaloids were evaluated for their cytotoxic effects on MCF-7, NCI-H460, and SF-268 cell lines by the MTT method. Only cephalinone-F (6) showed significant cytotoxicity.
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