Phenolic marine natural products as aldose reductase inhibitors
Sonia Manzanaro1, Javier Salva, Jesús Angel de la Fuente
1Instituto Biomar, S.A., Polígono Industrial, Edificio CEEI, 24231 Onzonilla, León, Spain.
Abstract:
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
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