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Related Experiment Video

Updated: Jul 19, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

[Macro creatine kinase: illness marker. Practical guide for the management].

M A Ruiz Ginés¹, M F Calafell Mas, J A Ruiz Ginés

¹Servicio de Análisis Clínicos y Bioquímica, Hospital Virgen de la Salud de Toledo, Complejo Hospitalario, Toledo. mangelrg@sescam.jccm.es

Anales De Medicina Interna (Madrid, Spain : 1984)

|October 28, 2006

Summary

Macro creatine kinase (Macro-CK) can cause false positive results for heart attacks. Type I Macro-CK is linked to cardiovascular issues, while Type II is associated with malignant tumors, indicating serious underlying conditions.

Related Experiment Videos

Last Updated: Jul 19, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Area of Science:

Clinical Chemistry
Biochemistry
Oncology

Background:

Macro creatine kinase (Macro-CK) is a complex of polymerized creatine kinase isoenzymes.
Macro-CK can interfere with diagnostic assays, leading to false elevations of CK-MB, complicating myocardial ischemia diagnosis.

Purpose of the Study:

To investigate the clinical significance of Macro-CK in emergency room patients.
To establish Macro-CK as a potential marker for specific underlying pathologies.
To provide recommendations for managing Macro-CK findings in emergency settings.

Main Methods:

Studied patients presenting to the emergency room over 16 months with Macro-CK.
Identified creatine kinase isoenzymes using agarose gel electrophoresis.

Main Results:

Macro-CK Type I (n=13) associated with cardiovascular disease (53.8%), diabetes (38.5%), and autoimmune conditions.
Macro-CK Type II (n=7) exclusively found in patients with malignant tumors (100%), particularly digestive and prostatic cancers with metastases.
Macro-CK Type II cases showed high mortality (71.4%) and were linked to mitochondrial damage in affected tissues.

Conclusions:

Macro-CK presence indicates significant underlying pathology.
Macro-CK Type I is prevalent in cardiac conditions, while Type II is indicative of tumoral disease.
An algorithm for managing Macro-CK in emergency departments is proposed.