Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Knowledge, Attitude and Practice on Covid-19 among Clinical Healthcare Workers in Bingham University Teaching Hospital (BHUTH) Jos, Plateau State, Nigeria.

West African journal of medicine·2021
Same author

Treatment of MOG antibody associated disorders: results of an international survey.

Journal of neurology·2020
Same author

Metronidazole-induced cytotoxic edema of corpus callosum: a case report.

Acta neurologica Belgica·2020
Same author

The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature.

Journal of neurology·2016
Same author

Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset.

Multiple sclerosis (Houndmills, Basingstoke, England)·2013
Same author

Long-term MRI findings in neuromyelitis optica: seropositive versus seronegative patients.

European journal of neurology·2013

Related Experiment Video

Updated: Jul 19, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Silent neurological involvement in Behçet's disease.

N Yesilot1, M Shehu, O Oktem-Tanor

  • 1Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Clinical and Experimental Rheumatology
|October 28, 2006
PubMed
Summary

Subclinical neurological involvement in Behçet's disease (BD) appears to be a milder form of the condition. Patients with silent neurological BD showed significantly lower mortality and disability rates compared to those with overt neuro-Behçet's disease.

More Related Videos

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Related Experiment Videos

Last Updated: Jul 19, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Behçet's disease (BD) is a multisystemic inflammatory disorder.
  • Neurological involvement, or neuro-Behçet's disease (NBD), significantly impacts patient prognosis.
  • Subclinical neurological involvement in BD remains poorly understood regarding its long-term course.

Purpose of the Study:

  • To investigate the long-term clinical course and prognosis of subclinical neurological involvement in Behçet's disease.
  • To compare the outcomes of patients with silent neurological involvement to those with overt neuro-Behçet's disease.

Main Methods:

  • A cohort study comparing patients with subclinical neurological findings (Silent Group) to those with overt parenchymal neuro-Behçet's disease (Overt Group).
  • Inclusion criteria required at least 8 years of follow-up.
  • Neurological assessment included magnetic resonance imaging (MRI) and neuropsychological testing.

Main Results:

  • The Silent Group (n=22) had a mean follow-up of 12.8 years. MRI abnormalities were found in 8/21 patients, and mild neuropsychological deficits in 15/20.
  • During follow-up, 3 patients in the Silent Group experienced overt neurological attacks. At the final visit, 21/22 patients were independent.
  • The Overt Group (n=51) showed significantly higher rates of dependency or mortality compared to the Silent Group (p=0.005).

Conclusions:

  • Subclinical neurological involvement in Behçet's disease represents a milder disease phenotype.
  • Patients with silent neurological BD demonstrate a significantly lower rate of mortality and disability.
  • Early identification and monitoring of subclinical neurological involvement may be crucial for managing Behçet's disease prognosis.