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Published on: May 17, 2019
[The relationship between expression of interleukin-8 and prognosis of breast cancer]
Chen Yao1, Shen-ming Wang, Dan Xie
1Center of Breast Disease, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Objective:
To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.
Methods:
Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.
Results:
The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).
Conclusions:
IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.