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11:39

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[Treatment of acneiform rash by epidermal growth factor inhibitors with oral tetracyclines]

Montse Fernández-Guarino1, Bibiana Pérez García, Isabel Aldanondo Fernández de la Mora

  • 1Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, España. montsefdez@msn.com

Actas Dermo-Sifiliograficas
|October 28, 2006
PubMed
Abstract

Insights

Doxycycline effectively treated acneiform rash caused by epidermal growth factor receptor (EGFR) inhibitors in a small study. Most patients experienced complete rash resolution with no relapses, suggesting doxycycline as a promising treatment option.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor (EGFR) inhibitors are novel antineoplastic agents.
  • Acneiform rash is a common side effect of EGFR inhibitor therapy, often requiring treatment.
  • Current treatment options lack definitive evidence of efficacy.

Purpose of the Study:

  • To evaluate the efficacy of doxycycline in treating EGFR inhibitor-induced acneiform rash.
  • To assess the resolution and recurrence rates of the rash under doxycycline treatment.

Main Methods:

  • A descriptive study involving 6 patients treated with doxycycline 100 mg daily for 3 weeks.
  • Analysis of patient clinical characteristics and treatment outcomes.
  • Long-term follow-up to monitor for rash relapse.

Main Results:

  • Five out of six patients achieved complete resolution of the acneiform rash.
  • One patient showed a partial response to doxycycline treatment.
  • No relapses were observed during extended follow-up periods, even with continued EGFR inhibitor therapy.

Conclusions:

  • Doxycycline demonstrates significant efficacy in managing EGFR inhibitor-induced acneiform rash.
  • The findings support doxycycline as an effective treatment option for this condition.
  • Further research may validate these promising results in larger cohorts.

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