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The effect of Fluosol-DA and Hespan haemodilution on S-warfarin elimination in the rat
1Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
The Journal of Pharmacy and Pharmacology
|September 1, 1990
Fluosol and Hespan haemodilution in rats did not change S-warfarin elimination within 72 h although previous studies had indicated that Fluosol haemodilution caused an increased cytochrome P450b and P450e activity at 48 h. This study showed that the increased activity at that time was specific for those isoenzymes.
Fluosol and Hespan haemodilution in rats did not change S-warfarin elimination within 72 h although previous studies had indicated that Fluosol haemodilution caused an increased cytochrome P450b and P450e activity at 48 h. This study showed that the increased activity at that time was specific for those isoenzymes.