Homocysteine and early re-stenosis after carotid eversion endarterectomy
A Assadian1, R Rotter, O Assadian
1Department of General and Vascular Surgery, Wilhelminenspital Vienna, Austria. afshin_assadian@yahoo.com
Summary
This study found no link between homocysteine (Hcy) levels and early re-stenosis after carotid endarterectomy. Higher creatinine and HbA1C were associated with re-stenosis, not Hcy.
Area of Science:
- Cardiovascular Surgery
- Vascular Medicine
- Biochemistry
Background:
- Homocysteine (Hcy) is implicated in intimal hyperplasia and arterial thrombosis.
- Understanding Hcy's role in post-surgical vascular events is crucial.
Purpose of the Study:
- To investigate the association between plasma homocysteine levels and early re-stenosis after carotid eversion endarterectomy.
Main Methods:
- 363 patients undergoing carotid eversion endarterectomy were assessed for preoperative homocysteine and risk factors.
- Clinical, homocysteine, and duplex follow-up was conducted up to 36 months post-surgery.
- Angiography was used for intraoperative assessment.
Main Results:
- Early re-stenosis (50-69% or >70%) occurred in 5.5% of patients.
- Higher serum creatinine and HbA1C levels were significantly associated with re-stenosis, occlusion, or stroke.
- No significant association was found between homocysteine levels and early re-stenosis, occlusion, or stroke.
Conclusions:
- Despite homocysteine being a known risk factor for atherothrombosis, this study found no association with early re-stenosis after carotid eversion endarterectomy.
- Creatinine and HbA1C may be more relevant predictors of adverse outcomes in this patient group.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:17Ischemic Heart Disease: Overview
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...