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Generalized lichen ruber planus--induced by radiotherapy of the breast?
Michael Eichbaum1, Wolfgang Harms, Sven Bolz
1Department of Gynecology and Obstetrics, University of Heidelberg Medical School, Heidelberg, Germany. Michael.Eichbaum@med.uni-heidelberg.de
Background:
Lichen ruber planus is an inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. The etiology is unknown.
Patients And Methods:
A 56-year-old female was treated with standard local radiotherapy after breast-conserving surgery due to high-grade ductal carcinoma in situ (DCIS) of the breast.
Results:
During radiotherapy, the patient began to complain about increasing disseminated itching papules of the breast. The efflorescences appeared as flat-topped, solid, purplish papules spreading to the limbs and trunk. A thorough clinical examination revealed additionally suspicious cob-web like and white-coated mucosal lesions of the oral cavity consistent with the clinical diagnosis of a generalized lichen ruber planus with an oral manifestation.
Conclusion:
To our knowledge, this is the first report of a generalized manifestation of lichen ruber planus presumably induced by radiation therapy.
