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Corneal ectasia after PRK: clinicopathologic case report.

Hyojin Kim¹, Jun-Sub Choi, Choun-Ki Joo

¹Department of Visual Optics, Division of Health Science, Baekseok University, Korea.

|October 28, 2006

Summary

Corneal ectasia developed 9 years after photorefractive keratectomy (PRK). Ultrastructural analysis revealed stromal degeneration but normal endothelium in this late complication of laser eye surgery.

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Area of Science:

Ophthalmology
Corneal Surgery
Laser Vision Correction

Background:

Photorefractive keratectomy (PRK) is a common laser eye surgery.
Corneal ectasia is a rare but serious complication following refractive surgery.

Observation:

A case of corneal ectasia presenting 9 years after PRK is described.
Clinical examination showed inferior topographic steepening and protrusion of corneal surfaces.
Advanced imaging revealed significant thinning of the cornea.

Findings:

Transmission electron microscopy (TEM) demonstrated degeneration of the epithelial basement membrane and stromal keratocytes.
Apoptotic keratocytes and extracellular matrix debris were observed within the corneal stroma.
Corneal endothelial cells remained morphologically normal.

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Implications:

This case highlights the potential for late-onset corneal ectasia after PRK.
Understanding the ultrastructural changes is crucial for managing this complication.
Further research is needed to elucidate the mechanisms of late ectasia after laser vision correction.