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Related Experiment Video

Updated: Jul 19, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Endothelial dysfunction and oxidative stress in sepsis].

O Parodi¹, B De Chiara, J Campolo

¹Istituto di Fisiologia Clinica del CNR, Milano. ifcnig@tin.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia

|October 28, 2006

Summary

Sepsis and septic shock involve endothelial dysfunction and oxidative stress due to complex biological responses. Targeting clinical biochemical markers and intervention timing may offer therapeutic strategies.

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Last Updated: Jul 19, 2026

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Published on: February 20, 2021

Area of Science:

Pathophysiology of critical illness
Endothelial biology
Oxidative stress mechanisms

Context:

Sepsis and septic shock are characterized by complex systemic responses.
Endothelial cell dysfunction is a key feature.
Oxidative stress plays a significant role.

Purpose:

To provide an overview of the pathophysiological mechanisms in sepsis and septic shock.
To highlight the roles of endothelial dysfunction and oxidative stress.
To suggest potential therapeutic targets.

Summary:

Altered endothelial cell function and oxidative stress are central to sepsis pathophysiology.
Endothelial dysfunction involves integrated responses including inflammatory mediators and the hemostatic system.
Oxidative stress arises from an imbalance in reactive oxygen species production and antioxidant defenses.

Impact:

Understanding these mechanisms can guide the identification of clinical biochemical markers.
Optimizing intervention timing is crucial for effective treatment.
This knowledge may lead to novel therapeutic strategies for sepsis and septic shock.