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D-serine in the developing human central nervous system.

Sabine A Fuchs1, Lambertus Dorland, Monique G de Sain-van der Velden

  • 1Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. s.fuchs@umcutrecht.nl

Annals of Neurology
|October 28, 2006
PubMed
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D-serine is crucial for human brain development, with levels highest at birth in healthy children. Deficiencies in D-serine impact brain development, but prenatal treatment may normalize levels and outcomes.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Developmental Biology

Background:

  • D-serine is an amino acid found in the central nervous system.
  • Its precise role in human brain development is not fully understood.
  • 3-phosphoglycerate dehydrogenase deficiency impairs L-serine biosynthesis, potentially affecting D-serine levels.

Purpose of the Study:

  • To investigate the role of D-serine in the human central nervous system.
  • To analyze D-serine, L-serine, and glycine concentrations in cerebrospinal fluid.
  • To compare levels between healthy children and those with 3-phosphoglycerate dehydrogenase deficiency.

Main Methods:

  • Cerebrospinal fluid samples were collected from healthy children and children with 3-phosphoglycerate dehydrogenase deficiency.

Related Experiment Videos

  • Concentrations of D-serine, L-serine, and glycine were measured.
  • Levels were analyzed in relation to age and treatment status.

    • Main Results:

    • Healthy newborns exhibited high D-serine concentrations, which decreased with age.
    • D-serine levels were nearly undetectable in untreated patients with 3-phosphoglycerate dehydrogenase deficiency.
    • A prenatally treated patient showed near-normal D-serine levels at birth and normal clinical phenotype.

    Conclusions:

    • D-serine plays a critical role in normal human brain development.
    • D-serine deficiency is associated with aberrant brain development.
    • Early intervention, potentially prenatal, may be crucial for managing D-serine related developmental disorders.