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Updated: Jul 19, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Chemotherapy practices and perspectives in invasive bladder cancer
Aude Flechon1, Jean-Pierre Droz
1Centre Léon Bérard, Department of Medical Oncology, 28 rue Laënnec, 69008 Lyon, France. flechon@lyon.fnclcc.fr
Expert Review of Anticancer Therapy
|October 31, 2006
Summary
Bladder cancer, the fifth most common cancer, affects adults, with infiltrative tumors posing a significant challenge. Research focuses on combining chemotherapy with targeted drugs to improve outcomes for advanced bladder cancer patients.
Area of Science:
- Oncology
- Urology
Background:
- Bladder cancer is the fifth most common malignancy in adults.
- While many superficial tumors are treated conservatively, 30% progress to infiltrative disease.
- Bladder cancer has a significant mortality rate of 30%.
Purpose of the Study:
- To review the current understanding of bladder cancer carcinogenesis and evolution.
- To outline current treatment strategies for infiltrative and advanced bladder cancer.
- To highlight future research directions in bladder cancer therapy.
Main Methods:
- Review of existing literature on bladder cancer treatment and molecular events.
- Analysis of standard chemotherapy regimens for advanced disease.
- Discussion of ongoing clinical trials and future therapeutic strategies.
Main Results:
- Radical cystectomy is the standard for infiltrative bladder cancer.
- Neoadjuvant chemotherapy improves outcomes prior to cystectomy.
- Standard chemotherapy regimens include MVAC and gemcitabine-cisplatin; paclitaxel combination is under study.
Conclusions:
- Adjuvant chemotherapy is under investigation.
- Current research emphasizes combining chemotherapy with targeted therapies.
- Future research should focus on gene methylation, cytokine-receptor activation, and signaling pathways for novel bladder cancer treatments.
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