Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting a local recurrence after breast-conserving therapy by gene expression profiling.

Dimitry S A Nuyten1, Bas Kreike, Augustinus A M Hart

  • 1Department of Radiation Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Breast Cancer Research : BCR
|October 31, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimation of accumulated dose to organs at risk in head and neck cancer patients treated with scheduled replanning and dose painting in the ARTFORCE trial.

Physics and imaging in radiation oncology·2026
Same author

Acute and long-term toxicity profiles and final oncologic outcomes in the phase III ARTFORCE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Dose de-escalation of elective neck irradiation in head and neck cancer: A secondary analysis of acute toxicity findings from the randomized controlled UPGRADE-RT trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

Comparing adaptive and dose redistributed radiotherapy to conventional radiotherapy in head and neck cancer - Quality of life results from the phase III ARTFORCE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

Clinical Benefit and Safety of Reduced Elective Dose in Definitive Radiotherapy for Head and Neck Squamous Cell Carcinoma: The UPGRADE-RT Multicenter Randomized Controlled Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Protocol compliance in a multicentric phase III trial investigating scheduled adaptive radiotherapy and dose painting in head and neck cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2024

Gene expression profiling can predict local recurrence in breast cancer patients after breast-conserving therapy. This wound-response signature identifies high-risk patients, improving personalized treatment strategies.

Area of Science:

  • Oncology
  • Genomics
  • Breast Cancer Research

Background:

  • Predicting ipsilateral recurrences after breast-conserving therapy is crucial for tailoring local treatment in breast cancer.
  • While age and intraductal component predict recurrence, many cases remain unpredictable.
  • Gene expression profiling offers a novel approach to identify patients at risk of local recurrence.

Purpose of the Study:

  • To identify gene expression profiles capable of predicting local recurrence in individual breast cancer patients.
  • To develop a classifier for local recurrence risk after breast-conserving therapy using microarray analysis.

Main Methods:

  • Utilized established gene expression profiles (wound-response signature, 70-gene prognosis profile, hypoxia-induced profile).
  • Trained a classifier to optimize the prediction of local recurrences in a training series.

Related Experiment Videos

  • Validated the wound-response signature's predictive performance.

    • Main Results:

    • The wound-response signature effectively separated patients into high (29% risk) and low (5% risk) recurrence groups at 10 years.
    • Achieved 87.5% sensitivity and 75% specificity in predicting local recurrence.
    • The developed classifier proved to be an independent predictor in multivariable analysis.

    Conclusions:

    • Gene expression profiling can identify subgroups of breast cancer patients at increased risk of local recurrence.
    • This approach aids in personalizing treatment and improving outcomes after breast-conserving therapy.