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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jul 19, 2026

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
07:58

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

Published on: July 27, 2015

Reperfusion injury: does it exist?

Garrett J Gross1, John A Auchampach

  • 1Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. ggross@MCW.EDU

Journal of Molecular and Cellular Cardiology
|October 31, 2006
PubMed
Summary

Reperfusion injury, damage from restoring blood flow to the heart, is a real phenomenon. New research on adenosine and opioid receptors, plus postconditioning and the RISK pathway, supports this concept.

Area of Science:

  • Cardiovascular Science
  • Myocardial Ischemia Research
  • Cellular Signaling Pathways

Background:

  • Reperfusion is critical for salvaging ischemic heart muscle.
  • The existence and mechanisms of reperfusion injury remain debated.
  • Understanding reperfusion injury is key to improving cardiac treatment outcomes.

Purpose of the Study:

  • To review evidence supporting the existence of reperfusion injury.
  • To highlight the role of adenosine and opioid receptor ligands in this context.
  • To introduce novel concepts: postconditioning (POC) and the reperfusion injury salvage kinase (RISK) pathway.

Main Methods:

  • Literature review of studies on myocardial reperfusion.
  • Analysis of research involving adenosine and opioid receptor ligands.

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A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure

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Last Updated: Jul 19, 2026

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
07:58

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

Published on: July 27, 2015

Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure
07:37

A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure

Published on: July 14, 2016

  • Examination of emerging concepts in reperfusion injury research.

    • Main Results:

    • Mounting evidence supports the occurrence of reperfusion injury.
    • Adenosine and opioid receptor ligands provide mechanistic insights.
    • Postconditioning (POC) and the RISK signaling pathway offer new perspectives.

    Conclusions:

    • Reperfusion injury is a validated phenomenon in cardiovascular science.
    • The RISK pathway and postconditioning represent significant advancements in understanding myocardial protection.
    • Further research into these pathways may lead to improved therapeutic strategies for heart attack patients.