Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ca2+ microdomains in smooth muscle.

John G McCarron1, Susan Chalmers, Karen N Bradley

  • 1Department of Physiology and Pharmacology, University of Strathclyde, SIPBS, Glasgow, UK. john.mccarron@strath.ac.uk

Cell Calcium
|October 31, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of cognitive screening tools in detecting possible dementia among older males in custody in Canada: a pilot study.

Health & justice·2026
Same author

VasoTracker 2: Open-source software and hardware for tracking blood vessel diameter and assessing vascular function.

The Journal of physiology·2025
Same author

Mitochondria regulate inositol triphosphate-mediated Ca<sup>2+</sup> release triggered by voltage-dependent Ca<sup>2+</sup> entry in resistance arteries.

The Journal of physiology·2025
Same author

Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension.

Hypertension (Dallas, Tex. : 1979)·2024
Same author

Recounting the untold stories of breast cancer patient experiences: lessons learned from a patient-public involvement and engagement storytelling event.

The International journal of pharmacy practice·2024
Same author

Signalling switches maintain intercellular communication in the vascular endothelium.

British journal of pharmacology·2024

Calcium (Ca2+) microdomains in smooth muscle enable localized signaling for cell functions. These specialized Ca2+ zones, generated by ion channels, are crucial for cellular processes.

Area of Science:

  • Cellular Biology
  • Physiology
  • Biochemistry

Background:

  • Calcium ions (Ca2+) regulate critical smooth muscle functions like cell division, contraction, and death.
  • Localized Ca2+ signaling via microdomains allows for precise control over these diverse cellular activities.

Purpose of the Study:

  • To review the mechanisms underlying the generation of Ca2+ microdomains in smooth muscle.
  • To discuss the role of Ca2+ influx and release from intracellular stores in microdomain formation.
  • To consider the contribution of organelles and modulators to Ca2+ microdomain dynamics.

Main Methods:

  • Literature review focusing on Ca2+ signaling and microdomain formation in smooth muscle.
  • Analysis of biophysical properties of Ca2+ channels and diffusion.

Related Experiment Videos

  • Examination of the roles of cellular compartments and regulatory molecules.

    • Main Results:

    • Ca2+ microdomains are formed by localized Ca2+ influx or release, creating high concentrations near channels.
    • These microdomains exhibit rapid concentration changes, enabling selective activation of effectors.
    • Factors like channel kinetics, buffering, clustering, and membrane barriers contribute to microdomain development.

    Conclusions:

    • Ca2+ microdomains are essential for targeted signaling in smooth muscle cells.
    • Understanding microdomain formation is key to comprehending Ca2+ regulation of cellular functions.
    • Further research into organelles and modulators will elucidate microdomain complexity.