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Related Experiment Video

Updated: Jul 19, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

Lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity.

Deborah K Vanderveen¹, Theresa A Mansfield, Eric C Eichenwald

¹Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. deborah.vanderveen@childrens.harvard.edu

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus

|October 31, 2006

Summary

Lowering oxygen saturation alarm limits for premature infants significantly reduced the incidence of retinopathy of prematurity (ROP). This simple change in oximetry policy offers a promising strategy for preventing ROP in high-risk newborns.

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Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

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How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

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Published on: August 19, 2020

Area of Science:

Neonatal medicine
Ophthalmology
Perinatal care

Background:

Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
Current management strategies aim to prevent ROP development and progression.

Purpose of the Study:

To evaluate the impact of adjusted oximetry alarm limits on ROP incidence and severity.
To determine if lowering oxygen saturation thresholds reduces ROP in high-risk infants.

Main Methods:

Implemented new oximetry alarm limits (85% and 93%) for infants with birth weight ≤1250g or gestational age ≤28 weeks.
Collected ROP data prospectively for one year post-policy change and compared it to the preceding three years.

Main Results:

A significant decrease in prethreshold ROP incidence was observed post-policy change (5.6% vs 17.5% in infants, p=0.01).
The rate of prethreshold ROP in eyes also significantly decreased (4.2% vs 16.7%, p=0.001).

Conclusions:

Adjusting oximeter alarm parameters is a simple yet effective method to reduce ROP incidence.
This policy change may decrease the occurrence of prethreshold ROP in vulnerable premature infants.