Related Experiment Video
Updated: Jul 19, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[Vitamin K epoxide reductase: Fresh blood for oral anticoagulant therapies]
1Inserm UMR-S775, service de toxicologie moléculaire, université René-Descartes, centre universitaire des Saints-Pères, 45, rue des Saints-Pères, 75006 Paris, France. marie-anne.loriot@univ-paris5.fr
Introduction:
Vitamin K epoxide reductase complex subunit I (VKORC1) is a key enzyme in the vitamin K cycle, cofactor required for the activation of vitamin K-dependent clotting factors.
Exegesis:
VKORC1 recycles vitamin K 2,3 epoxide back to active vitamin K hydroquinone, an important factor for the carboxylation step of clotting factors. VKORC1 is the target enzyme of inhibition by oral anticoagulants or anti-vitamin K (warfarin, acenocoumarol).
Conclusion:
We show here the clinical consequences of genetic variations of VKORC1 during VKA therapy.
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